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Don’t Just “Watch & Wait” -
Natural Medicine Support for CLL
(Chronic Lymphocytic Leukaemia)


Article provided by :

Belle McCaleb ND, RN, MSS-C, BSN, RYT - Adelaide

Specialising in women's health and cancer support.


Chronic lymphocytic leukaemia is a progressive disease where abnormal white blood cells are produced in high quantity and accumulate causing “crowding out” of normal blood cells.  A hallmark of the disease is the ability of the CLL cells to avoid programmed cell death or apoptosis.

Many patients diagnosed with CLL are told to simply watch and wait until the disease progresses to the point where it has significant negative impact at which time treatment my be undertaken (usually with chemotherapy). Natural medicine takes the view that we can intervene sooner rather than later with nutritional and herbal approaches to try to slow the progression of the disease.

Research into the nutritional status of CLL patients has identified two key nutritional deficiencies: antioxidants and Vitamin D.

As far back as 1998 Kumerova et al found a decrease in antioxidant defense and an increase in resultant red cell damage in CLL patients.

In 2011 Shanafelt et al stated “vitamin D insufficiency is an independent risk factor in this disease” (CLL).  Furthermore they found Vitamin D levels related strongly to prognosis – the lower they were the worse the prognosis; eg the more rapid the progression of disease. 

Other nutrients have been reviewed in relationship to leukaemia types other than CLL.

For example in 2004 Kennedy et al found low levels and or intakes of Vitamin C, Vitamin E, Betacarotene and Vitamin A have been associated with more severe treatment side effects in children with Acute Lymphoblastic Leukaemia (ALL).

In addition to repleting nutritional status in patients with CLL, it may be useful to use herbal & nutritional approaches that might slow the progression of the disease. 

The most effective class of natural medicines against CLL seem to be those that can induce leukaemia cell death (apoptosis).  Apoptosis inducers, including natural ones, are reviewed in a 2014 article by Christian Billard.

According to Billard’s extensive review the most potent natural medicines against CLL include apigenin, green tea extract (EGCG), St John’s wort extract (hyperfoin), trans-reveratrol, quercetin, curcumin, Hops (xanthohumol), Aglaia foveolata (silvestrol) and a Cotton seed extract (gossypol).  An additional apoptosis inducer reported by Battle et al is an extract of Magnolia (honokiol).

So rather than just “watching and waiting” if you or a loved one is living with CLL consider getting professional naturopathic/herbalist advice regarding support.

Please note that “strong immune boosting” herbs are often contraindicated as the issue in CLL is not low immune cell status but high abnormal immune cell status. One would not want to inadvertently stimulate more abnormal cell production.

It is important to note that there are additional considerations and contraindications particularly if under treatment or very low in platelets as a result of the disease thus the recommendation to professional advice.



Kumerova A et al, Anemia and antioxidant defence of the red blood cells. Mater Ped Pol, 1998.30(1-2)

Shanafelt T et al , Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia. Blood 2011;117(5):1492-1498

Kennedy D et al Low antioxidant vitamin intakes are associated with an increase in adverse effects of chemotherapy in children with ALL, American Journal of Clinical Nutrition, Vol. 79, No. 6, 1029-1036, June 2004

Billard C, Apoptosis inducers in chronic lymphocytic leukemia, Oncotarget. 2014 Jan; 5(2): 309–325

Battle T et al, The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells, Blood Jul 2005, 106 (2) 690-697


The information provided in this article is intended for general use and for personal interest only. It should not be used or understood as suggestion or medical advice.

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Belle McCaleb - Naturoath and Herbalist - Adelaide


Naturopath & Herbalist Adelaide

Belle McCaleb is an accredited and experienced naturopath, medical herbalist, nutritionist, Master's prepared counsellor, registered yoga instructor, registered yoga therapist and registered nurse specialising in women's health and cancer support. She is also a certified Live Blood Assessment and Genetic Profiling practitioner. 

Belle McCaleb - Naturoath and Herbalist - Adelaide

Belle McCaleb


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